Plasma Level of Soluble ST2 in Chronically Infected HIV-1 Patients with Suppressed Viremia

نویسندگان

  • Mehwish Younas
  • Christina Psomas
  • Vikram Mehraj
  • Renaud Cezar
  • Pierre Portales
  • Edouard Tuaillon
  • Adeline Guigues
  • Jacques Reynes
  • Pierre Corbeau
  • Jean-Pierre Routy
چکیده

INTRODUCTION Interleukin-33 (IL-33) is a cell damage-induced alarmin. The plasma concentration of suppression of tumorogenicity (sST2), a surrogate marker of IL-33 production, is a prognostic marker of cardiovascular disease. OBSERVATION Recently, we reported that sST2 plasma levels were elevated in early HIV-1 infection and linked to markers of microbial translocation and of T cell activation. RESULTS Here we show that it is not the case in patients with suppressed viremia. Thus, IL-33 plays its alarmin role only during the early phase of the infection.

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عنوان ژورنال:

دوره 11  شماره 

صفحات  -

تاریخ انتشار 2017